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Application Report: Unraveling the Mystery of Neurons

Application Report: Unraveling the Mystery of Neurons

An assay method that correlates ion channel currents with neuronal excitability in hiPSC-derived dementia neurons is introduced.

Human induced pluripotent stem cells (hiPSCs) are a highly versatile platform for modeling human neurons, enabling the generation of excitatory neurons for in vitro models. To understand the electrophysiological properties of neurons, such as excitability and synaptic transmission, recording ion channels in hiPSC-derived neurons is key. Researchers can investigate healthy neurophysiological functions by capturing the dynamics of ion channel currents, such as sodium, potassium, and calcium, as well as explore dysfunctions related to neurological disorders like epilepsy, autism, and neurodegenerative diseases. These models provide valuable tools for studying disease mechanisms and testing potential therapeutic interventions in patient-specific contexts. *For more details, please refer to the related links. Feel free to contact us for more information.*

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Application Report: How to Optimize Records in Cardiac Electrophysiology

Application Report: How to Optimize Records in Cardiac Electrophysiology

Describing how to optimize recordings in cardiac electrophysiology using the Qube 384 perforated patch clamp.

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the potential to revolutionize heart disease modeling and drug screening. However, capturing physiologically relevant action potentials (APs) has been challenging, especially with traditional whole-cell (WC) patch-clamp methods. WC recordings often disrupt the cellular environment and can shorten AP duration due to the "washing out" of cytoplasmic components. By using perforated patch-clamp techniques, it is possible to maintain electrical access while preserving cell integrity. Unlike WC, the perforated method uses agents like nystatin to create small pores in the cell membrane, allowing ions to pass while retaining important cytoplasmic components. Applying this method has significantly improved AP recordings on the Sophion Qube 384 platform, demonstrating a success rate of up to 40%. *For more details, please refer to the related links. Feel free to contact us for further information.*

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Application Report <High-Throughput APC Record>

Application Report <High-Throughput APC Record>

High-throughput APC recordings of hippocampal neurons highlight their promise in improving treatment for cognitive dysfunction, mental illness, and schizophrenia.

A PhD from the University of Copenhagen has made significant progress by using the Qube 384 automated patch clamp (APC) platform to record α5-containing GABAA receptors from acutely isolated primary neurons. This research highlights the importance of using natural primary hippocampal neurons to evaluate the effects of antipsychotic drugs on GABAergic activity, particularly from the perspective of drug discovery for cognitive function and schizophrenia. Previous studies relied on heterologous expression systems, such as HEK cells expressing α5-containing GABAA receptors. However, this research emphasizes the value of investigating these effects in primary hippocampal neurons, which more accurately reflect physiological conditions. *For more details, please refer to the related links. Feel free to contact us for further information.*

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Application Report: Fluorescence-Activated Cell Sorting

Application Report: Fluorescence-Activated Cell Sorting

Describing a method to rescue low-expressing cells and perform efficient APC assays.

The Kv1.3 ion channel regulates the activation of T lymphocytes and controls membrane potential and calcium signaling in immune responses. Dysregulation is associated with autoimmune diseases such as multiple sclerosis, psoriasis, and rheumatoid arthritis. The Kv1.3 channel also plays a role in the proliferation and survival of cancer cells. Therefore, the Kv1.3 channel is considered a promising target for the treatment of both autoimmune diseases and cancer. Efficient ion channel assays require consistent, robust, and functional membrane expression. Using a low-expressing Kv1.3 cell line, we classified cells based on Kv1.3 expression using the Tyto cell sorter (from Miltenyi Biotec), significantly improving the success rate of QPatch assays. *For more detailed information, please refer to the related links. Feel free to contact us for more details.*

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